Mary&May Spicule Azelaic PDRN Spot Cream is a targeted treatment cream designed to improve the appearance of blemishes, clogged-looking pores, post-blemish marks, redness, and uneven texture. Its active formula combines Azelaic Acid, Salicylic Acid, Tea Tree Leaf Water, Zinc PCA, Niacinamide, Madecassoside, Panthenol, Sodium DNA, and micro-spicules derived from Hydrolyzed Sponge to support clearer, smoother, and more balanced-looking skin.
Benefits:
- Supports blemish-prone skin: Azelaic Acid, Salicylic Acid, Tea Tree ingredients, Zinc PCA, and Niacinamide help improve the appearance of active blemishes and congestion.
- Refines clogged-looking pores: Salicylic Acid and micro-spicules help remove dull surface buildup and improve the appearance of uneven pore texture.
- Improves post-blemish marks: Niacinamide and Azelaic Acid help brighten dull marks and promote a more even-looking skin tone.
- Helps reduce visible redness: Madecassoside, Centella Asiatica Extract, Panthenol, Allantoin, and Azelaic Acid support a calmer-looking complexion.
- Balances excess-oil appearance: Zinc PCA, Niacinamide, Tea Tree Leaf Water, and Salicylic Acid help support oily and blemish-prone skin.
- Supports the moisture barrier: Panthenol, Ceramide NP, Cholesterol, Hydrogenated Lecithin, Sodium Hyaluronate, and nourishing lipids help reduce moisture loss.
- Smooths uneven texture: Micro-spicules and exfoliating ingredients help rough, congested skin appear more refined with gradual use.
- Provides soothing hydration: Glycerin, Panthenol, Polyglutamic Acid, Sodium Hyaluronate, and Allantoin help maintain moisture and comfort.
Skin Types: Combination • Oily • Blemish-prone • Congested skin • Experienced sensitive skin that tolerates spicules and active ingredients
Skin Concerns: Active blemishes • Post-blemish marks • Clogged-looking pores • Excess oil • Uneven texture • Temporary redness • Dullness • Weakened moisture barrier
Clinical & Testing Notes:
- Completed a primary skin irritation test according to the supplied product information.
- Described as non-comedogenic and suitable for acne-prone skin according to the supplied product information.
- The supplied product information reports clinical testing for improvements in visible hyperpigmentation and soothing effects.
- No sample size, complete study conditions, or measured results were supplied, and individual results may vary.
Formula Notes:
- The supplied promotional information states that the formula contains 2% Azelaic Acid, 5% Niacinamide, 3,000 ppm Zinc PCA, 1% Panthenol, and 3,000 ppm micro-spicules. These exact percentages are not displayed in the supplied INCI.
- Hydrolyzed Sponge is the ingredient corresponding to the formula’s micro-spicules. The supplied information describes them as 80–300 μm in size.
- Micro-spicules do not physically open or permanently shrink pores. They create a mild stimulating exfoliating sensation that may help improve the appearance of roughness and congestion.
- Contains both Azelaic Acid and Salicylic Acid, so the product should be introduced gradually.
- Sodium DNA is listed in the formula, but its source and whether it corresponds to the branded CICA PDRN claim cannot be confirmed from the supplied INCI alone.
- No Fragrance or Parfum is listed, but the formula contains Tea Tree Leaf Oil and aromatic components including Limonene, Alpha-Terpinene, Pinene, Terpineol, and Terpinolene.
- The product should not be described as vegan because Hydrolyzed Sponge is listed and the source of Sodium DNA is not specified.
- A prickling or tingling sensation may occur due to the micro-spicules. Strong burning, swelling, or persistent irritation is not expected and use should be discontinued if it occurs.
- This product can support blemish-prone skin but is not a medical acne treatment.
How to Use:
- Use after cleansing and toner, preferably in the evening when first introducing the product.
- Apply a small amount directly to blemish-prone areas or a thin, even layer over areas with congestion, following the instructions on the packaging.
- Press gently into the skin rather than rubbing vigorously, as friction may intensify the spicule sensation.
- Avoid the eyelids, immediate eye area, lips, corners of the nose, and broken or severely irritated skin.
- Follow with a gentle moisturizer if additional barrier support is needed.
- Begin 2–3 evenings per week and gradually increase frequency only if the skin remains comfortable.
- Avoid using facial scrubs, peeling devices, microneedling tools, or other spicule products in the same routine.
- Avoid layering with strong AHA/BHA treatments, Retinol, Retinal, prescription retinoids, or Benzoyl Peroxide in the same routine if your skin is sensitive.
- Apply broad-spectrum sunscreen every morning and reapply during prolonged sun exposure.
Key Ingredients:
- Azelaic Acid – Helps improve the appearance of blemishes, redness, uneven tone, post-blemish marks, and congested texture.
- Niacinamide – Helps brighten dull marks, support oil balance, refine the appearance of pores, and strengthen the moisture barrier.
- Salicylic Acid – A BHA that helps clear dead skin buildup from oily, clogged-looking pores.
- Hydrolyzed Sponge – Provides the formula’s micro-spicules, which help stimulate surface renewal and refine rough-looking texture.
- Tea Tree Leaf Water & Tea Tree Leaf Oil – Help support a clearer, fresher-looking complexion.
- Zinc PCA – Helps balance the appearance of excess oil and support blemish-prone skin.
- Madecassoside – A Centella-derived ingredient that helps soothe and support stressed-looking skin.
- Centella Asiatica Extract – Helps calm visible discomfort and support the moisture barrier.
- Panthenol – Helps hydrate, soothe dryness, and maintain barrier comfort.
- Allantoin – Helps soften and soothe sensitive-feeling skin.
- Sodium DNA – Helps condition the skin and support a smoother, hydrated-looking finish.
- Ceramide NP, Cholesterol & Hydrogenated Lecithin – Help reinforce the moisture barrier and reduce moisture loss.
- Sodium Hyaluronate & Polyglutamic Acid – Help attract and retain moisture for a softer skin feel.
- Magnolol & Honokiol – Provide antioxidant and skin-conditioning care.
- Shea Butter, Macadamia Seed Oil & Sunflower Seed Oil – Help nourish and soften dry areas.
- Tocopherol – Vitamin E that provides antioxidant and skin-conditioning support.
Ingredients:
Water, Melaleuca Alternifolia (Tea Tree) Leaf Water, Propylene Glycol, Niacinamide, Glycerin, Azelaic acid, Dipropylene Glycol, Ammonium Acryloyldimethyltaurate/VP Copolymer, Polypropylsilsesquioxane, Methylpropanediol, Panthenol, Caprylic/Capric Triglyceride, 1,2-Hexanediol, C14-22 Alcohols, Sodium Hydroxide, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyacetophenone, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Stearate, Polyisobutene, Tromethamine, Salicylic Acid, Hydrolyzed Sponge, Zinc PCA, Cetyl Ethylhexanoate, Vinyl Dimethicone, Macadamia Ternifolia Seed Oil, C12-20 Alkyl Glucoside, Brassica Campestris (Rapeseed) Sterols, Polyglyceryl-10 Laurate, Ethylhexylglycerin, Tocopherol, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Cholesterol, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Erythritol, Allantoin, Helianthus Annuus (Sunflower) Seed Oil, Caprylyl/Capryl Glucoside, Butyrospermum Parkii (Shea) Butter, Xanthan Gum, Sorbitan Oleate, Lauryl Glucoside, Hydrogenated Lecithin, Sodium Hyaluronate, Polyglyceryl-6 Laurate, Copper Chlorophyll, Polyglutamic Acid, Myristyl Glucoside, Disodium EDTA, Ceramide NP, Glyceryl Acrylate/Acrylic Acid Copolymer, Madecassoside, Stearic Acid, PVM/MA Copolymer, Magnolol, Honokiol, Rosmarinus Officinalis (Rosemary) Extract, Oleic Acid, Centella Asiatica Extract, Caprylyl Glycol, Butylene Glycol, Sodium DNA, Limonene, Alpha-Terpinene, Hexamethylindanopyran, Pinene, Terpineol, Terpinolene
FAQ:
Q: What does Mary&May Spicule Azelaic PDRN Spot Cream help with?
A: It helps improve the appearance of active blemishes, clogged-looking pores, post-blemish marks, redness, excess oil, and uneven texture.
Q: Is it a spot treatment or a full-face cream?
A: It can be applied to targeted blemish-prone areas. The supplied directions also describe applying a thin layer across the face, so follow the packaging instructions and begin with targeted use if your skin is sensitive.
Q: Does it contain 2% Azelaic Acid?
A: The supplied promotional information states that it contains 2% Azelaic Acid. The exact percentage is not displayed in the supplied INCI.
Q: Does it contain 5% Niacinamide?
A: The supplied promotional information states that it contains 5% Niacinamide. The exact percentage is not displayed in the supplied ingredient list.
Q: Does it contain Salicylic Acid?
A: Yes. Salicylic Acid is listed in the supplied INCI and helps refine oily, clogged-looking pores.
Q: What are micro-spicules?
A: Micro-spicules are tiny structures represented by Hydrolyzed Sponge in the ingredient list. They create a mild prickling sensation and help support surface exfoliation and smoother-looking texture.
Q: Does it contain 3,000 ppm of micro-spicules?
A: The supplied product information states that the formula contains micro-spicules at 3,000 ppm. This concentration is not displayed in the INCI.
Q: Do the spicules open clogged pores?
A: No ingredient physically opens pores. The spicules and exfoliating ingredients may help remove surface buildup and make congested pores look clearer and more refined.
Q: Is a tingling or prickling sensation normal?
A: Mild prickling may occur due to the micro-spicules. Stop use if you experience strong burning, swelling, intense redness, or discomfort that does not settle.
Q: Can it help active pimples?
A: Azelaic Acid, Salicylic Acid, Tea Tree ingredients, Niacinamide, and Zinc PCA can support blemish-prone skin. It is not a medical acne treatment.
Q: Can it help post-acne marks?
A: Niacinamide and Azelaic Acid can help improve the appearance of brown or dull post-blemish marks with consistent use and daily sunscreen.
Q: Can it help with redness?
A: Azelaic Acid, Madecassoside, Centella Asiatica Extract, Panthenol, and Allantoin may help reduce the appearance of temporary redness.
Q: Does it contain Zinc PCA?
A: Yes. Zinc PCA is listed in the supplied INCI, and the promotional information states a concentration of 3,000 ppm.
Q: Does it contain PDRN?
A: Sodium DNA is listed in the ingredient list. Its source and whether it corresponds to the branded CICA PDRN complex cannot be confirmed from the INCI alone.
Q: Is it vegan?
A: It should not be described as vegan because Hydrolyzed Sponge is listed and the source of Sodium DNA is not specified.
Q: Is it non-comedogenic?
A: The supplied product information states that it completed non-comedogenic testing. Individual skin responses may still vary.
Q: Is it suitable for sensitive skin?
A: The product completed a primary irritation test according to the supplied information, but it contains spicules, Azelaic Acid, Salicylic Acid, Tea Tree Oil, and aromatic components. Sensitive skin should patch test and introduce it gradually.
Q: Does it contain fragrance?
A: No Fragrance or Parfum is listed, but it contains Tea Tree Leaf Oil and aromatic components including Limonene, Alpha-Terpinene, Pinene, Terpineol, and Terpinolene.
Q: Can I use it every day?
A: Begin 2–3 evenings per week. Increase gradually only if the skin remains comfortable and shows no persistent irritation.
Q: Can I use it with Retinol or Retinal?
A: Avoid using them in the same routine at first. Alternate nights to reduce the risk of dryness and irritation.
Q: Can I use it with AHA, BHA, or exfoliating toners?
A: The formula already contains Salicylic Acid and micro-spicules. Avoid additional strong exfoliants in the same routine, especially if your skin is sensitive.
Q: Can I use it with Benzoyl Peroxide?
A: It is safer to alternate them rather than layer them in the same routine, particularly during the adjustment period.
Q: Can I use it after shaving, waxing, or professional treatments?
A: Avoid applying it immediately after shaving, waxing, laser treatments, microneedling, or strong peels because the skin may be more sensitive.
Q: Do I need sunscreen while using it?
A: Yes. Apply broad-spectrum sunscreen every morning to protect the skin and prevent post-blemish marks from becoming more visible.
Q: Where can I find Mary&May skincare in Cyprus?
A: You can find this Mary&May spot cream at Just Cosmetics, together with a curated selection of Korean Cosmetics in Cyprus.

















